In powder and granule processing and manufacturing such as Oral Solid Dosage (OSD), the inline, real-time application of Process Analytical Technology (PAT) such as Near-Infrared (NIR) and Raman spectroscopy presents unique challenges, ranging from prohibitive material costs in developing chemometric models to significant challenges in physically integrating PAT probes into batch and continuous unit operations.
Based on concepts developed and tested over many years at one of the world’s largest pharmaceutical companies, we have commercialised several engineering solutions to the above problems. Adopted globally by over 15 of the top 20 pharmaceutical innovator companies, our devices enable and support the real-time prediction of various Critical Process Parameters (CPPs) such as blend uniformity, loss on drying and particle size distribution, across blending, granulating, drying and tabletting unit operations, for both batch and continuous manufacturing.
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